Yes, There Are Times

P30: Are There Anxious Genes?

Anxiety comprises many clinical descriptions and phenotypes. A genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. Extensive genetic studies of the serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT) gene have revealed how variation in gene expression can be correlated with anxiety phenotypes. Complete genome-wide linkage s...

Yes , Virginia , There is a Santa Claus

The bulk of this paper is a finegrained critical analysis of a single argument. Such detailed treatment, unusual though it is in a journal article, is warranted for a number of reasons, I think . First, a clear understanding of the particular argument in question demands close attention. Different arguments can, and do, warrant different degrees, kinds, and depths of analysis, and the one under...

"Yes, Virginia, there is a Santa Claus".

Yes, Virginia, there will be healthcare reform.

More than 100 years ago, a young girl named Virginia O'Hanlon wrote a letter to Santa Claus. 1 A newspaper reporter, impressed by the girl's innocence, edi-torialized this quest to believe in a fantasy representing good in the world by penning the famous line, " Yes, Virginia, there is a Santa Claus. " This story came to mind a few weeks ago, when I was having breakfast with my daughter-in-law ...

Interactions between the circadian clock and metabolism: there are good times and bad times.

An endogenous circadian (∼24 h) clock regulates rhythmic processes of physiology, metabolism and behavior in most living organisms. While able to free-run under constant conditions, the circadian clock is coupled to day : night cycles to increase its amplitude and align the phase of circadian rhythms to the right time of the day. Disruptions of the circadian clock are correlated with brain dysf...